Navigating Complexity: Perspectives on Risk Assessment in the Era of New Blood-based Tests for Early Cancer Detection
BLOODPAC’s Early Detection and Screening (ED&S) Working Group has published its latest paper, titled "Navigating Complexity: Perspectives on Risk Assessment in the Era of New Blood-based Tests for Early Cancer Detection." This publication builds on the important discussions from our AACR 2024 session, “Rethinking Cancer Risk and Risk Assessment for Liquid Biopsy-Based Single- and Multi-Cancer Screening,” and highlights the ongoing efforts of the Working Group.
The article captures the Working Group’s discussions on:
1) risk assessment including considerations for adapting historical SCD risk terminology, such as “average risk” and “elevated risk” to MCD tests;
2) the implications of this terminology for describing intended use populations; and
3) the existing gaps in evidence for determination of absolute risks.